PRA
Progressive Retinal Atrophy is
an inherited form of blindness in dogs that occurs in two forms: generalized
PRA and central PRA. Generalized PRA is primarily a photoreceptor disease
and is the form found in Tibetan Spaniels. The clinical signs have been
observed between 1½ and 4 years, but as late at seven years.
What are the signs to look for?
The earliest clinical sign is "night blindness." The dog cannot
see well in a dimly lit room or at dusk. The dog will show a reluctance
to move from a lighted area into darker surroundings. The night blindness
develops progressively into complete blindness.
How can you know for sure your dog is
affected with PRA?
The only way to be sure is to have your dogs eyes examined by
a Veterinarian who specializes in Ophthalmology. Once examined and found
to be clear from PRA, the dog is registered (in the United States) with CERF - Canine Eye Registration Foundation.
Is this CERF registration good for life?
No, CERF registration is good for twelve months from the examination
date. It does not indicate whether or not the dog carries the PRA gene.
Is there any treatment?
No, this condition is hereditary and if your dog carries the genes for
PRA, it will develop.
What effect will it have on your dog?
Even though your dog will become completely blind, the condition is painless.
Many dogs adjust to their loss of sight and do just fine in their own
surroundings.
How is PRA inherited?
PRA is inherited as a simple autosomal recessive gene. The dog
must inherit this recessive gene from both parents. If it receives the
gene from only one parent, it will not be affected. However, it will
be known as a carrier as it can pass this gene on to its own progeny.
How do you prevent PRA?
It is extremely important for anyone considering to breed their
dog to have its eyes certified. If the dog is positive for PRA, it should
not be bred. The testing should be done on an annual basis. By identifying
the affected dogs, it is easier to identify
the carriers. Also see "Safeguarding
Tibbies".
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Weeping Eyes
"Weeping Eyes" is one of those vague symptoms that can
be the result of any number of different causes. Some tearing in Tibbies
is attributable the natural configuration of the face. The combination
of facial hair, facial fullness, "bulky eyelids" and "tight" lower
lids. What apparently happens is the fullness of the face may push the
facial hair against the eyes, irritate then and cause tearing. Some of
the tears drain away through the nose (as they are supposed to do) but
when there are a few too many tears, there's no place for them to go
except to overflow those tight lower lids onto the face. Facial hair
also sometimes acts like a "wick" to draw the tears onto the
face. In most cases this really isn't anything to worry about with no
consequence other than cosmetic.
NOTE: If there is ever any question,
you should have your pet examined by your vet or a veterinary ophthalmologist.
Cherry Eye
"Cherry Eye" is actually a prolapsed third eyelid. What
happens is that the eyelid becomes "loose" allowing one of
the tear glands to protrude. Tacking is the recommended procedure that
should only be done by a qualified vet or a veterinary ophthalmologist.
For more information on any eye problems, I recommend the articles
on either the or Eye Vet Consulting or the Animal
Eye Care sites.
Allergies
Among the less serious health problems a Tibetan Spaniel is susceptible
to is allergies. This is not unique to Tibbies as allergies appear to
be on the rise among all dogs. Things to be on the lookout for are very
similar to human allergies symptoms such as watery eyes and scratching.
Probably the number one allergic reaction among all dogs is to fleas.
The dogs are allergic not to the bite, but the flea saliva.
In most cases, allergies are is easily treatable with proper diet and
flea prevention. Allergies
in Pets
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Anesthesia
Isoflourane is probably one of the safest anesthesia available. The
recovery time is very quick and there is almost no groggy after effects.
Some
vets feel Tibbies use very little anesthesia for their weights, hence
their "sensitivity". An overdose can be fatal. To minimize
the risk of anesthesia, your vet can do tests to screen for potential
problems prior to any surgery or procedure. Tips.
Dysplasia
Hip and elbow dysplasia are more commonly found in the large breed dogs.
There have been a few rare incidents among Tibetan Spaniels. For more
information, check with The
Orthopedic Foundation for Animals, Inc.
Poisonous Plants & Medications
There are many plants and medications around your home that can be very
toxic or even deadly to your pet. Plants such as oleander, azaleas, rhododendrons,
poinsettias and Japanese yews are just a few of the common plants that
can pose a threat to your dog's health. It is a good idea to keep all
medications, gardening supplies and questionable plants out of reach
from your pet. Visit the Training
Your Puppy page for tips on making your house safe for your pets.
The American Veterinary Medical Association (AMVA)
has a wonderful website that should answer most of the questions you
have about your pet's health.
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Outdoor Problems
A few members of the Tibetan Spaniel
Global Village have been unfortunate enough to have their dog meet
up with a skunk. While some say that plain tomato juice will work,
many say that it takes several washings and a lot of juice. However,
not to worry, one of the best ways to de-skunk your dog is to wash
him/her with the following mixture:
- One quart hydrogen peroxide
- 1/4 cup baking soda
- Teaspoon of dishwashing detergent
Contributed by Jacki Scarborough
Many of your local pet stores as well as many of your
online pet stores have
products specifically aimed at taming some of the worst pet odors.
Older Pets
As our pets begin to age, they are affected
by many of the same problems their owners face as they age. Articular
cartilage plays an important
role in optimal joint function. As they age, sometimes cartilage loses
its ability to replenish itself. The most common supplement recommended
is Cosequin.
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Liver Shunt - Portosystemic Shunt
A portosystemic shunt is an abnormal vessel that allows blood
to bypass the liver. As a result the blood is not cleansed by one of
the bodies filters: the liver. This condition is often referred
to as a "liver shunt".
What are the signs?
Most shunts cause recognizable by the time a dog is a young adult
but once in a while one is diagnosed at a later time in life. Since
the severity of the condition can vary widely depending on how much
blood flow is
diverted past the liver it is possible for a lot of variation in
clinical signs & time of onset for the signs to occur. Often,
this condition is recognized after a puppy fails to grow, making
an early diagnosis pretty common. Signs of portosystemic shunts include
poor weight gain, sensitivity to sedatives (especially diazepam),
depression, pushing the head against a solid object, seizures, weakness,
salivation, vomiting, poor appetite, increased drinking and urinating,
balance problems and frequent urinary tract disease or early onset
of bladder stones. If these
signs increase dramatically after eating, it is a strong supportive
sign of a portosystemic shunt.
CLINICAL DIAGNOSIS OF HEPATIC PORTO-SYSTEMIC
SHUNTS
by Larry Snyder, DVM
Clinical Signs
Most dogs will be diagnosed with port-systemic shunts under one year
of age, but dogs as old as eight have been diagnosed with the condition.
Animals are usually stunted, thin, depressed, have trouble gaining
weight, and are usually characterized by the owners as chronic "poor doers".
In most affected dogs there will be some degree of behavioral signs ranging
from listlessness, apathy, or depression to more severe signs of circling,
head pressing, stupor, drooling, blindness, or convulsions, some leading
to coma. These behavioral changes are due to an accumulation of toxins
(especially ammonia) that affect the brain causing a condition called
Hepatic Encephalopathy. These toxins are most abundant in the blood stream
following the dog eating, especially a high protein meal, & may remain
high for hours afterward. Not all dogs with the shunt will show this
meal associated behavioral change, but in 25% of the affected dogs that
do, the diagnosis becomes clearer. A high percent of affected animals
show an intolerance to anesthetics or tranquilizers, & will show increased
recovery times following use of these products. Even anti-convulsants
used to control seizures may be potentially dangerous if allowed to concentrate
in a dog with functional shunt. Approximately 75% of affected individuals
will show digestive system symptoms including poor appetite, ascites,
vomiting, drooling, diarrhea, or occasionally deranged appetite (eating
paper, etc.). Urinary system symptoms may include increased thirst and
urination, & in a majority of porto-systemic shunt cases, there
will be crystals or stones formed in the urinary tract. These crystals
will be either uric acid or ammonium urate (ammonium biurate or
thorn-apple
crystals.). There can be bladder stones formed or crystals may
be noted
on the hair around the prepuce or vulva.
Laboratory Findings
Routine performed serum chemistries are fairly nonspecific toward
confirming the diagnosis of porto-systemic shunts, but there may
be a decreased
total protein (primarily albumin), decreased blood glucose, decreased
cholesterol, & decreased blood urea nitrogen (BUN). The uric acid levels
may be elevated in a significant number of affected individuals. Acid
levels are extremely important in the diagnostic screening of symptomatic
potential shunts. Fasting and 2-hr. post meal blood samples are evaluated
for bile acid levels. In virtually all porto-systemic shunts there will
be a significant rise in the bile acid levels over normal. The use of
bile acids in screening clinically normal dogs for liver shunts is not
currently being advised due to the variation of normal bile acid levels
in Yorkshire Terriers, & other breeds as well. Reports of recent vaccination
with modified-live vaccines causing high serum bile acid levels in normal
animals have not been confirmed as of this time. Liver function testing
with Bromosulfaphthalein (BSP) or ammonia tolerance testing are sensitive & reliable
if performed correctly. These tests measure the liver's ability to excrete/detoxify
known agents, and thus measure liver function accurately. Radiography.
Radiography is one of the most important methods of establishing a diagnosis
of porto-systemic shunt, & is currently the only universally accepted
method of confirming a shunt, short of major surgery. Injection of a
radiopaque dye into the spleen (Splenoportograpy) will show the shunt
on radiographs & allow accurate assessment for surgical correction. Nuclear
Medicine. The placement of a radiopharmaceutical agent (radioisotope)
specific for the liver into the colon for absorption through the mucosa
has been gaining favor because of its noninvasive diagnostic value. This
procedure requires expensive equipment & the diagnosis is based
on the distribution of the radionuclide in the lung or heart compared
to that
in the liver. This procedure also does not identify the exact location
of the shunt for surgical correction if required.
Ultrasound
Until recently, ultrasound was fairly unreliable for nonsurgical
diagnosis of porto-systemic shunts. With the advent of Color Flow
Ultrasound,
there is the potential for diagnosis of this condition on non-anesthetized
animals. At the present time, this technology appears to be the
diagnostic procedure of choice. If currently undertaken research
confirms its
value,
Color Doppler Ultrasound will soon be the preferred screening and
diagnostic tool. At the present time, Hepatic Porto-Systemic shunts
are considered
to be UNQUESTIONABLY genetic by some of the leading canine experts,
but the mode has not been identified at the present time; research
is being
conducted at Michigan State University to identify this pattern.
Genetic disorders in dogs can spread relatively rapidly if a dog,
whether affected
or a carrier, is a well-respected animal in either conformation
or ability, and is used extensively for breeding. This is especially
true in the
case of the male that can produce hundreds of offspring during
his
breeding life. If the cause of such a condition can be discovered,
then a working
strategy can be implemented to control and eliminate the disorder.
The Yorkshire Terrier Club of America Foundation, Inc. is currently
funding
research into both the genetic nature of the problem & into the use of
Color Flow Doppler Ultrasound as a diagnostic & screening tool. These
steps will hopefully become the basis for setting up an open registry
for Yorkshire Terriers & other affected breeds to hopefully eliminate,
or at least minimize the problem within each breed.
Liver Shunt
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